Over the past seasons, in which Al Duhail participated in the AFC Champions League, the Sepahan team was drawn into one group with Al Duhail only once in the 2012 season in group C along with Al Ahly of Saudi Arabia, Al Nasr of the UAE.
The two teams met in the first match on April 3, 2012 at Naqsh Jahan Stadium in Isfahan with Sepahan team winning two goals to one goal for by Ali Afif.

The two teams met in the return match on April 18, 2012 at Thani Bin Jassim Stadium, and Al Duhail managed to win that match with a goal scored by Bakari Kone.

Among the previous confrontations, the two teams met in two matches, Al Duhail won one match, Sepahan won one match, and each team scored two goals against the other team.